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Women's Health Weekly

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Breast Cancer



Findings from McGill University broaden understanding of breast cancer



August 7th, 2008

"Bone marrow-derived mesenchymal stromal cells (MSCs), beneficial for regenerative medicine applications due to their wide differentiation capabilities, also hold promise as cellular vehicles for the delivery of therapeutic plasma-soluble gene products due to their ease of handling, expansion, and genetic engineering. We hypothesized that MSCs, gene enhanced to express interleukin-12 (IL-12) and then embedded in a matrix, may act as an anticancer neo-organoid when delivered s.c. in autologous/syngeneic hosts," scientists in Montreal, Canada report.

"We performed such experiments in mice and noted that primary murine MSCs retrovirally engineered to secrete murine IL-12...


Source: Women's Health Weekly (2008-08-07)

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