Women's Health Weekly
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Breast Cancer
Findings from W.J. Zhang and co-authors broaden understanding of breast cancer
August 7th, 2008
According to recent research published in the journal Cytokine, "IL-4-induced Stat6 signaling is active in a variety of cell types, including immune cells and cancer cells, and plays an important role in the regulation of gene expression. Using EMSA gel shift assay and an antibody to Stat6, we phenotyped two breast cancer cell lines, ZR-75-1 being active Stat6(high) phenotype and BT-20 being defective Stat6(null) phenotype, respectively." "Breast cancer cells carrying Stat6(null) phenotype exhibited increased spontaneous apoptosis compared with those carrying Stat6(high) phenotype. Expression microarray analyses demonstrated that IL-4 upregulated CCL26, SOCS1,...
Source: Women's Health Weekly (2008-08-07)
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