Women's Health Weekly
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Breast Cancer
Recent findings in breast cancer described by researchers from Royal College of Surgeons
August 7th, 2008
"Associations between p160 coactivator proteins and endocrine resistance have been described. Though thought to primarily interact with steroid receptors, the p160 proteins can also interact with non-nuclear receptor transcription factors including the MAP kinase effector proteins Ets," scientists writing in the journal Oncogene report. "Here, we observed that in breast cancer cells resistant and insensitive to endocrine treatment, the growth factor EGF induced Ets-2 but not Ets-1 transcriptional regulation of the oncogene myc. Ets-2 regulation of myc was found to be reliant on the p160 proteins SRC-1 and SRC-3. In support of these molecular observations, strong...
Source: Women's Health Weekly (2008-08-07)
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