Women's Health Weekly
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Breast Cancer
Recent findings from University of Queensland highlight research in breast cancer
August 14th, 2008
"Recent studies have identified novel subgroups in ER-negative breast cancer based on the expression pattern of androgen receptor (AR). One subtype ( molecular apocrine) has an over-expression of steroid-response genes and ErbB2," scientists writing in the journal Neoplasia report. "Using breast cancer cell lines with molecular apocrine features, we demonstrate a functional cross-talk between AR and ErbB2 pathways. We show that stimulation of AR and ErbB2 pathways leads to the cross-regulation of gene expression for AR, ErbB2, FOXA1, XBP1, TFF3, and KLK3. As opposed to the physiologic transient phosphorylation of extracellular signal-regulated kinase (ERK1/2)...
Source: Women's Health Weekly (2008-08-14)
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