Women's Health Weekly
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Breast Cancer
Reports outline breast cancer research from C.C.C. Wang and colleagues
August 14th, 2008
"Norsolorinic acid, isolated from the Aspergillus nidulans, was investigated for its antiproliferative activity in human breast adenocarcinoma MCF-7 cells. To identity the anticancer mechanism of norsolorinic acid, we assayed its effect on apoptosis, cell cycle distribution, and levels of p53, p21/WAF1, Fas/APO-1 receptor and Fas ligand," scientists in Tainan, Taiwan report. "The results showed that norsolorinic acid induced apoptosis of MCF-7 cells without mediation of p53 and p21/WAF1. We suggest that Fas/Fas ligand apoptotic system is the main pathway of norsolorinic acid-mediated apoptosis of MCF-7 cells," wrote C.C.C. Wang and colleagues. The...
Source: Women's Health Weekly (2008-08-14)
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