Women's Health Weekly
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Breast Cancer
Research on breast cancer published by scientists at Thomas Jefferson University
August 14th, 2008
According to a study from the United States, "Oncogene-mediated signaling to the host environment induces a subset of cytokines and chemokines. The Drosophila Dac gene promotes migration of the morphogenetic furrow during eye development." "Expression of the cell-fate determination factor Dachshund (DACH1) was lost in poor prognosis invasive breast cancer. Mouse embryo fibroblasts derived from Dachl(-/-) mice demonstrated endogenous Dachl constitutively represses cellular migration. DACH1 inhibited cellular migration and invasion of oncogene (Ras, Myc, ErbB2, c-Raf)-transformed human breast epithelial cells. An unbiased proteomic analysis identified and...
Source: Women's Health Weekly (2008-08-14)
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