Women's Health Weekly
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Breast Cancer
Studies from K. Yonemori et al further understanding of breast cancer
August 14th, 2008
"Denosumab, a fully human monoclonal antibody to receptor activator of nuclear factor-kappa B ligand (RANKL), suppresses bone resorption. This open-label, multicenter, phase 1 study evaluated the safety, pharmacodynamics, and pharmacokinetics of denosumab in Japanese women with breast cancer-related bone metastases," researchers in Tsukiji, Japan report. "Patients (n = 18; median age, 57 years) received a single subcutaneous injection of denosumab 60 mg or 180 mg or three doses of denosumab 180 mg on days 1, 29, and 57 (every 4 weeks) and were followed for >= 141 days. No major safety concerns related to denosumab were noted in any cohort. All patients experienced at...
Source: Women's Health Weekly (2008-08-14)
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