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Women's Health Weekly

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Cancer



Research conducted at L. Mathews and co-researchers has updated our knowledge about cancer



August 14th, 2008

"The pathways and key players that regulate parity-induced protection against breast cancer, conferred by estrogen (E) and progesterone (P), have not fully been explained. Interestingly, in rodents, high levels of circulating insulin-like growth factor-I (IGF-I) appear to block this parity-induced protection," scientists writing in the European Journal of Cancer Prevention report.

"Using an in-vitro mouse mammary gland whole organ culture system, we investigated the mechanisms by which IGF-I affects the protective effects of E + P. Earlier studies have demonstrated that important changes induced by parity include both the enhanced sensitivity to p53 activation,...


Source: Women's Health Weekly (2008-08-14)

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