Colon Cancer Genetics
Findings from Erasmus University, Josephine Nefkens Institute advance knowledge in colon cancer genetics
Published in Women's Health Weekly, August 21st, 2008
Investigators publish new data in the report 'CHEK2 1100delC Is a Susceptibility Allele for HNPCC-Related Colorectal Cancer.' According to a study from Rotterdam, Netherlands, "The pathogenic CHEK2 1100delC variant is firmly established as a breast cancer susceptibility allele. Dutch CHEK2 1100delC breast cancer families frequently also include colorectal cancer cases, and the variant is particularly prevalent among breast cancer families with hereditary breast and colorectal cancer."
"Yet, it is still unclear whether CHEK2 1100delC also confers a colorectal cancer risk independent of its breast cancer risk. CHEK2 1100delC was genotyped in the index cases of 369 Dutch...
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