Women's Health Weekly
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Breast Cancer
Research in the area of breast cancer reported from University of Nebraska
August 21st, 2008
According to recent research from the United States, "Previous studies from our laboratory have shown that the activation of G(2)-M checkpoint after exposure of MCF-7 breast cancer cells to gamma-irradiation (IR) is dependent on the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) signaling. Studies presented in this report indicate that IR exposure of MCF-7 cells is associated with a marked increase in expression of breast cancer 1 (BRCA1) tumor suppressor, an effect that requires ERK1/2 activation and involves posttranscriptional control mechanisms." "Furthermore, reciprocal coimmunoprecipitation, as well as colocalization studies, indicate an...
Source: Women's Health Weekly (2008-08-21)
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