Women's Health Weekly
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Breast Cancer
Research on breast cancer described by scientists at Loyola University Chicago
August 21st, 2008
According to a study from the United States, "High expression of Notch-1 and Jagged-1 mRNA correlates with poor prognosis in breast cancer. Elucidating the cross-talk between Notch and other major breast cancer pathways is necessary to determine which patients may benefit from Notch inhibitors, which agents should be combined with them, and which biomarkers indicate Notch activity in vivo." "We explored expression of Notch receptors and ligands in clinical specimens, as well as activity, regulation, and effectors of Notch signaling using cell lines and xenografts. Ductal and lobutar carcinomas commonly expressed Notch-1, Notch-4, and Jagged-1 at variable levels....
Source: Women's Health Weekly (2008-08-21)
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