Women's Health Weekly
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Breast Cancer
Research results from City Hospital update knowledge of breast cancer
August 21st, 2008
"MUC1 is a high molecular weight glycoprotein that is overexpressed in breast cancer. Aberrant O-linked glycosylation of MUC1 in cancer has been implicated in disease progression," researchers in Nottingham, the United Kingdom report. "We investigated the O-linked glycosylation of MUC1 purified from the serum of an advanced breast cancer patient. O-Glycans were released by hydrazinolysis and analyzed by liquid chromatography-electrospray ionization-mass spectrometry and by high performance liquid chromatography coupled with sequential exoglycosidase digestions. Core 1 type glycans (83%) dominated the profile which also confirmed high levels of sialylation: 80% of the...
Source: Women's Health Weekly (2008-08-21)
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