Women's Health Weekly
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Breast Cancer
Studies from A. Subtilrodriguez and co-researchers update current data on breast cancer
August 21st, 2008
According to recent research published in the journal Molecular and Cellular Biology, "Steroid hormone receptors regulate gene expression, interacting with target DNA sequences but also activating cytoplasmic signaling pathways. Using the human 11 beta-hydroxysteroid dehydrogenase type 2 (11 beta-HSD2) gene as a model, we have investigated the contributions of both effects on a human progesterone-responsive promoter in breast cancer cells." "Chromatin immunoprecipitation has identified two different mechanisms of hormone-induced progesterone receptor (PR) recruitment to the 11 beta-HSD2 promoter: (i) direct PR binding to DNA at the proximal promoter, abrogated...
Source: Women's Health Weekly (2008-08-21)
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