Women's Health Weekly
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Cancer
Studies from Z.Y. Zhang et al have provided new data on cancer
August 28th, 2008
According to recent research published in the journal Cancer Chemotherapy and Pharmacology, " Eribulin mesylate (E7389), a structurally simplified, synthetic analog of the marine natural product halichondrin B, acts by inhibiting microtubule dynamics via mechanisms distinct from those of other tubulin-targeted agents. Eribulin is currently in Phase III clinical trials for the treatment of metastatic breast cancer." "Since drug-induced modulation of cytochrome P450 enzymes, particularly CYP3A4, is a frequent cause of drug-drug interactions, we examined the effects of eribulin on the activity and expression of hepatic and recombinant CYP3A4 (rCYP3A4) in vitro. ...
Source: Women's Health Weekly (2008-08-28)
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