Cancer Gene Therapy
Researchers from Orekhovich Institute of Biomedical Chemistry describe findings in cancer gene therapy
Published in Women's Health Weekly, September 11th, 2008
Researchers detail in 'Implication of alpha5beta1 integrin in invasion of drug-resistant MCF-7/ADR breast carcinoma cells: a role for MMP-2 collagenase,' new data in cancer gene therapy. "Expression of alpha5beta1 integrin in the drug-resistant MCF-7/ADR breast carcinoma cells was inhibited by treatment of these cells with alpha5-specific siRNA. The decrease of alpha5beta1 expression resulted in a sharp decrease of expression of MMP-2 collagenase and inhibition of invasion activity of these cells in vitro," investigators in Russia report.
"Similar decrease of invasion was also observed during inhibition of MMP-2 expression by treatment of these cells with MMP-2-specific...
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