Breast Cancer

New findings from Y. Wang and co-authors describe advances in breast cancer

Published in Women's Health Weekly, September 11th, 2008

"Cyclin D1 is a key mediator of cell cycle progression that is aberrantly regulated in multiple cancers, especially in breast cancers. A number of studies have indicated that a polymorphism in a splice donor site in the cyclin D1 gene is associated with alternative splicing and the production of the alternative cyclin D1b transcript," scientists writing in the journal Cancer Research report.

"Furthermore, this polymorphism is selectively associated with disease outcomes. However, relatively little is known regarding the protein product of the alternatively spliced message, cyclin D1b. Using antibodies specific for cyclin D1b, it was found that this protein is...

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Source: Women's Health Weekly (2008-09-11)

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