Women's Health Weekly
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Breast Cancer
Research data from University of Regensburg update understanding of breast cancer
September 11th, 2008
"Cell cycle arrest of malignant cells is an important option for cancer treatment. In this study, we modified the structure of antimitotic 2-phenylindole-3-carbaldehydes by condensation with hydrazides of various benzoic and pyridine carboxylic acids," scientists in Regensburg, Germany report. "The resulting hydrazones inhibited the growth of MDA-MB 231 and MCF-7 breast cancer cells with IC50 values of 20-30 nM for the most potent derivatives. These 2-phenylindole derivatives also exerted an inhibitory effect on the growth of both proliferating and resting U-373 MG glioblastoma cells. Though the hydrazones exhibited similar structure-activity relationships as the...
Source: Women's Health Weekly (2008-09-11)
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