Women's Health Weekly
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Breast Cancer
Researchers at Fudan University target breast cancer
September 11th, 2008
According to a study from Shanghai, People's Republic of China, " Estrogen receptor alpha (ER alpha) mediates the growth stimulation of estrogen in breast cancer cells and is a useful predictive factor for response to endocrine therapy. It is reported that ER alpha was induced in ER alpha negative breast cancer cells by both DNA methyltransferase-1 (DNMT1) inhibitor 5-aza-2'-deoxycytidine (AZA) and histone deacetylase (HDAC) inhibitor trichostatin A (TSA)." "However, whether the breast cancer cells with induced ER alpha restore response to endocrine therapy requires to be further researched. Patients and methods Reverse transcriptase-polymerase chain reaction (RT-PCR)...
Source: Women's Health Weekly (2008-09-11)
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