Women's Health Weekly
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Breast Cancer
Researchers from National Institutes of Health report on findings in breast cancer
September 11th, 2008
According to recent research published in the journal Molecular and Cellular Biology, "FANCJ mutations are associated with breast cancer and genetically linked to the bone marrow disease Fanconi anemia (FA). The genomic instability of FA-J mutant cells suggests that FANCJ helicase functions in the replicational stress response." "A putative helicase with sequence similarity to FANCJ in Caenorhabditis elegans (DOG-1) and mouse (RTEL) is required for poly(G) tract maintenance, suggesting its involvement in the resolution of alternate DNA structures that impede replication. Under physiological conditions, guanine-rich sequences spontaneously assemble into...
Source: Women's Health Weekly (2008-09-11)
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