Women's Health Weekly
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Breast Cancer
Studies from O. Mccormack et al further understanding of breast cancer
September 11th, 2008
According to recent research published in the journal Breast Cancer Research and Treatment, " Oestrogen receptor alpha (ER alpha) is traditionally measured on all breast tumour specimens to identify those patients more likely to respond to anti-oestrogens. Progesterone receptor (PR) status has contributed useful information in defining more responsive subgroups." "PR negativity may be a marker for increased signalling through growth factor receptor tyrosine kinase pathways. Progesterone acts through two PRs, PRA and PRB. PRB, the functionally active PR, can be silenced by promoter hypermethylation. Following DNA and RNA extraction from 94 breast carcinomas, the...
Source: Women's Health Weekly (2008-09-11)
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