Women's Health Weekly
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Breast Cancer
Studies from University Hospital reveal new findings on breast cancer
September 11th, 2008
"The CpG island spanning the transcription start of the glutathione S-transferase P1 becomes methylated in a variety of human cancers including breast cancer. To study the effect of sequence variation on hypermethylation of the GSTP1 promoter, we analyzed the genetic and epigenetic variability in 90 tumors from patients with locally advanced breast cancer," scientists writing in the journal Cancer Research report. "High-resolution quantitative analysis revealed large variability in the DNA methylation levels. Lack of methylation was more often observed in the basal and normal-like estrogen receptor (ER)-negative tumors, and methylated GSTP1 was associated with...
Source: Women's Health Weekly (2008-09-11)
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