Women's Health Weekly
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Endometrial Cancer
Studies from Vanderbilt University have provided new information about endometrial cancer
September 11th, 2008
According to recent research from the United States, "Etiology of endometrial cancer (EMC) is not fully understood. Animal models with rapidly and spontaneously developing EMC will help explore mechanisms of cancer initiation and progression." "Pten(+/-) mice are currently being used as a model to study EMC. These females develop atypical endometrial hyperplasia of which similar to 20% progresses to EMC. In addition, tumors develop in other organs, complicating the use of this model to specifically study EMC. Here, we show that conditional deletion of endometrial Pten results in EMC in all female mice as early as age 1 month with myometrial invasion occurring by 3...
Source: Women's Health Weekly (2008-09-11)
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