Women's Health Weekly
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Enzyme Research
Reports from University of Saarland add new data to research in enzyme research
September 11th, 2008
According to recent research from Saarbrucken, Germany, "The 17 beta-hydroxysteroid dehydrogenase type 1 (17 beta-HSD1) catalyses the reduction of the weakly active estrone (E1) into the most potent estrogen, 17 beta-estradiol (E2). E2 stimulates the growth of hormone-dependent diseases via activation of the estrogen receptors (ERs). 17 beta-HSD1 is often over-expressed in breast cancer cells." "Thus, it is an attractive target for the treatment of mammary tumours. The combination of a ligand-and a structure-based drug design approach led to the identification of bis(hydroxyphenyl) azoles as potential inhibitors of 17 beta-HSD1. Different azoles and hydroxy substitution...
Source: Women's Health Weekly (2008-09-11)
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