Women's Health Weekly
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Breast Cancer
New findings in breast cancer described from University of Texas
September 18th, 2008
"Myeloid cell leukemia-1 (Mcl-1), a Bel-2-like antiapoptotic protein, plays a role in cell immortalization and chemoresistance in a number of human malignancies. A peptidylprolyl cis/trans isomerase, Pinl is involved in many cellular events, such as cell cycle progression, cell proliferation, and differentiation through isomerizing prophosphorylated substrates," investigators in the United States report. "It has been reported that down-regulation of Pint induces apoptosis, and that Erk phosphorylates and upregulates Mcl-1; however, the underlying mechanisms for the two phenomena are not clear yet. Here, we showed that Pin I stabilizes Mcl-1, which is required for Mcl-I...
Source: Women's Health Weekly (2008-09-18)
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