Women's Health Weekly
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Breast Cancer
Research by S. Caporali and colleagues in breast cancer provides new insights
September 18th, 2008
"The phosphatidylinositol 3-kinase/AKT pathway is activated frequently in human cancer, and it has been implicated in tumor cell proliferation, survival, and chemoresistance. In this study, we addressed the role of AKT in cellular responses to the therapeutic methylating agent temozolomide (TMZ), and we investigated the possible link between TMZ-induced modulation of AKT function and activation of ataxia-telangiectasia and Rad3-related (ATR)- and ataxia telangiectasia mutated (ATM)-dependent signaling pathways," researchers in Rome, Italy report. "We found that clinically relevant concentrations of TMZ caused activation of endogenous AKT in lymphoblastoid cells, and in...
Source: Women's Health Weekly (2008-09-18)
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