Women's Health Weekly
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Cancer
Investigators at Stanford University release new data on cancer
September 18th, 2008
"Malignant tumors are capable of degrading the surrounding extracellular matrix, resulting in local invasion or metastasis. Urokinase-type plasminogen activator (uPA) and its cell surface receptor (uPAR) are central molecules in one of the major protease systems involved in extracellular matrix degradation," scientists writing in the journal Clinical Cancer Research report. "Noninvasive imaging of this receptor in vivo with radiolabeled peptides that specifically target uPAR may therefore be useful to decipher the potential invasiveness of malignant lesions. In this study, we developed a Cu-64-labeled uPAR-binding peptide for positron emission tomography (PET)...
Source: Women's Health Weekly (2008-09-18)
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