Women's Health Weekly
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Bioengineering
Scientists at Mayo Clinic report research in bioengineering
September 25th, 2008
According to a study from the United States, "In this study, we establish an MCF-7 xenograft model that mimics the progression of human breast carcinomas typified by loss of p53 integrity, development of centrosome amplification, acquired estrogen receptor (ER alpha) heterogeneity, overexpression of Mdm2 and metastatic spread from the primary tumor to distant organs. MCF-7 cells with abrogated p53 function (vMCF-7D(np53)) maintained nuclear ERa expression and normal centrosome characteristics in vitro." "However, following mitogen stimulation, they developed centrosome amplification and a higher frequency of aberrant mitotic spindles. Centrosome amplification was...
Source: Women's Health Weekly (2008-09-25)
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