Women's Health Weekly
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Breast Cancer
Research from Johns Hopkins University, Medical Department in the area of breast cancer published
September 25th, 2008
"Benzo[a] pyrene diol epoxide (BPDE), the active metabolite of benzo[a] pyrene present in tobacco smoke, is a major cancer-causing compound. To evaluate the effects of BPDE on human breast epithelial cells, we exposed an immortalized human breast cell line, MCF 10A, to BPDE and characterized the gene expression pattern," scientists writing in the journal Oncogene report. "Of the differential genes expressed, we found consistent activation of DDX3, a member of the DEAD box RNA helicase family. Overexpression of DDX3 in MCF 10A cells induced an epithelial-mesenchymal- like transformation, exhibited increased motility and invasive properties, and formed colonies in...
Source: Women's Health Weekly (2008-09-25)
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