Women's Health Weekly
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Breast Cancer
Study findings from Boston University broaden understanding of breast cancer
September 25th, 2008
"Tamoxifen remains an important adjuvant therapy to reduce the rate of breast cancer recurrence among patients with oestrogen-receptor-positive tumours. Cytochrome P-450 2D6 metabolises tamoxifen to metabolites that more readily bind the oestrogen receptor," scientists in the United States report. "This enzyme also metabolises selective serotonin reuptake inhibitors (SSRI), so these widely used drugs - when taken concurrently - may reduce tamoxifen's prevention of breast cancer recurrence. We studied citalopram use in 184 cases of breast cancer recurrence and 184 matched controls without recurrence after equivalent follow-up. Cases and controls were nested in a...
Source: Women's Health Weekly (2008-09-25)
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