Women's Health Weekly
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Cancer
Researchers from McGill University report recent findings in cancer
September 25th, 2008
"The transcription factor GATA3 has recently been shown to be necessary for mammary gland morphogenesis and luminal cell differentiation. There is also an increasing body of data linking GATA3 to the estrogen receptor alpha (ER alpha) pathway," researchers in Montreal, Canada report. "Among these it was shown that GATA3 associates with the promoter of the ER alpha gene and ER alpha can reciprocally associate with the GATA3 gene. GATA3 has also been directly implicated in a differentiated phenotype in mouse models of mammary tumourigenesis. The purpose of our study was to compare coexpressed genes, by meta-analysis, of GATA3 and relate these to a similar analysis for ER...
Source: Women's Health Weekly (2008-09-25)
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