Women's Health Weekly
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Cervical Cancer
Studies from Columbia University in the area of cervical cancer published
September 25th, 2008
According to recent research from the United States, "Copy number gains and amplifications are characteristic feature of cervical cancer (CC) genomes for which the underlying mechanisms are unclear. These changes may possess oncogenic properties by deregulating tumor-related genes." "Gain of short arm of chromosome 5 (5p) is the most frequent karyotypic change in CC. To examine the role of 5p gain, we performed a combination of single nucleotide polymorphism (SNP) array, fluorescence in situ hybridization (FISH), and gene expression analyses on invasive cancer and in various stages of CC progression. The SNP and FISH analyses revealed copy number increase (CNI) of 5p in...
Source: Women's Health Weekly (2008-09-25)
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