Women's Health Weekly
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Colon Cancer
Research from Medical College of Wisconsin, Medical College provides new data on colon cancer
September 25th, 2008
According to recent research published in the journal Gastroenterology, "CXCL12 and CXCR4 signaling plays critical roles in development, homeostasis, and tumor metastasis. Previously, we have shown that epigenetic silencing of CXCL12 in colorectal. and mammary carcinomas promotes metastasis." "Anoikis is an essential process of colonic epithelial turnover and limits the metastatic progression of carcinoma. We sought to determine the role for anoikis in limiting tumor metastasis following reexpression of CXCL12 in human colorectal carcinoma cells. Tumor formation and metastasis of colonic carcinoma cells was monitored using in vivo bioluminescence imaging. Anoikis...
Source: Women's Health Weekly (2008-09-25)
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