Women's Health Weekly
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Endometrial Cancer
Studies conducted at A. Dutt et al on endometrial cancer recently published
September 25th, 2008
According to recent research from the United States, "Oncogenic activation of tyrosine kinases is a common mechainism of carcinogenesis and, given the druggable nature of these enzymes, an attractive target for anticancer therapy." "Here, we show that somatic mutations of the fibroblast growth factor receptor 2 (FGFR2) tyrosine kinase gene, FGFR2, are present in 12% of endometrial carcinomas, with additional instances found in lung squamous cell carcinoma and cervical carcinoma. These FGFR2 mutations, many of which are identical to mutations associated with congenital craniofacial developmental disorders, are constitutively activated and oncogenic when ectopically...
Source: Women's Health Weekly (2008-09-25)
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