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Women's Health Weekly

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Yale University



Discovery challenges fundamental tenet of cancer biology



September 25th, 2008

Yale researchers have identified an unusual molecular process in normal tissues that causes RNA molecules produced from separate genes to be clipped and stitched together. The discovery that these rearranged products exist in normal as well as cancerous cells potentially complicates the diagnosis of some cancers and raises the possibility that anti-cancer drugs like Gleevec could have predictable side effects.

The work is reported in the journal Science.

"Our findings are surprising because we identified in normal cells certain types of gene products— so called chimeric RNAs and proteins—thought to be found only in cancerous cells or in cells on...


Source: Women's Health Weekly (2008-09-25)

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