Women's Health Weekly
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Apoptosis
Data on apoptosis published by researchers at University of North Texas
September 25th, 2008
"Protein kinase C epsilon (PKC epsilon) acts as an antiapoptotic protein and inhibits tumor necrosis factor-alpha (TNF)-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in MCF-7 breast cancer cells. Members of the TNF receptor superfamily trigger apoptosis independent of the tumor suppressor protein p53, which primarily affects DNA damage-induced apoptosis," scientists writing in the journal Oncogene report. "We have previously shown that PKCe acts upstream of Akt to inhibit receptor-initiated cell death. Since Akt can regulate p53, we have examined the involvement of p53 in PKC epsilon-mediated TRAIL resistance. Overexpression of PKCe in MCF-7 cells...
Source: Women's Health Weekly (2008-09-25)
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