Alzheimer Disease

New Alzheimer disease findings from T.A. Ishunina and co-authors described

Published in Women's Health Weekly, October 2nd, 2008

According to a study from Netherlands, "A role of estrogens in brain aging and Alzheimer's disease (AD) is a hot topic of research. We show in material of 71 patients that the estrogen receptor alpha (ER alpha.) splice variant MB1 is expressed at the protein and mRNA level in the human brain."

"MB1 is mainly confined to astrocytes, membranes and cytoplasm of projecting neurons and endothelial cells. It was consistently observed in the thalamus, colliculus inferior, pontine nuclei, dorsal motor nucleus of vagus,'some motor neurons in the anterior and lateral horns of the spinal cord and rarely in pyramidal neurons of the cerebral cortex. The highest level of MB1...

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Source: Women's Health Weekly (2008-10-02)

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