Women's Health Weekly
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Breast Cancer
Research from G. Ortizferron and co-authors in the area of breast cancer published
October 2nd, 2008
According to recent research published in the journal Cell Research, "The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL/APO2L) is a member of the TNF gene superfamily that induces apoptosis upon engagement of cognate death receptors. While TRAIL is relatively non-toxic to normal cells, it selectively induces apoptosis in many transformed cells." "Nevertheless, breast tumor cells are particularly resistant to the effects of TRAIL. Here we report that, in combination with the cyclin-dependent kinase inhibitor roscovitine, exposure to TRAIL induced marked apoptosis in the majority of TRAIL-resistant breast cancer cell lines examined....
Source: Women's Health Weekly (2008-10-02)
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