A report, 'CYP2A6 activity in a healthy Spanish population: effect of age, sex, smoking, and oral contraceptives,' is newly published data in Human and Experimental Toxicology. "This study was performed to assess the influence of age, sex, smoking, and contraceptive use on CYP2A6 activity. In the metabolism of caffeine, the conversion of 1,7 dimethylxanthine (17X) to 1,7 dimethiylurate (17U) is catalyzed primarily by CYP2A6," researchers in Zaragoza, Spain report.
"CYP2A6 phenotype was determined by the urinary ratio 17U:17X in the interval of 4-5 h after caffeine intake in 179 healthy white Spaniards (102 women and 76 men). There were 99 non-smokers and 80...
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