Women's Health Weekly
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Breast Cancer
Research from University of Leuven provide new insights into breast cancer
October 2nd, 2008
"Mutations in the BRCA1-interacting DEAH helicase Brip1 confer an increased risk of breast cancer. In the present study we aimed to unravel the transcriptional control of Brip1 and to determine its expression levels in a set of 101 primary invasive breast carcinomas," scientists in Leuven, Belgium report. "Transcription of Brip1 was found to be cell growth-related and controlled by the E2F/retinoblastoma (Rb) pathway through a conserved E2F-responsive site. Repression of Brip1 expression by the cell growth-inhibiting compound 1 alpha,25-dihydroxyvitamin D-3 depended on this same E2F-responsive site. In spite of its role as a tumor suppressor, both quantitative reverse...
Source: Women's Health Weekly (2008-10-02)
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