Women's Health Weekly
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Breast Cancer
Research on breast cancer reported by scientists at East Carolina University, Medical Department
October 2nd, 2008
"Ectopic expression of mutant forms of phosphatase and tensin homologue deleted on chromosome 10 ( PTEN) lacking lipid ( G129E) or lipid and protein ( C124S) phosphatase activity decreased sensitivity of MCF-7 breast cancer cells, which have wild-type PTEN, to doxorubicin and increased sensitivity to the mammalian target of rapamycin ( mTOR) inhibitor rapamycin. Cells transfected with a mutant PTEN gene lacking both lipid and protein phosphatase activities were more resistant to doxorubicin than cells transfected with the PTEN mutant lacking lipid phosphatase activity indicating that the protein phosphatase activity of PTEN was also important in controlling the sensitivity to doxorubicin,...
Source: Women's Health Weekly (2008-10-02)
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