Women's Health Weekly
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World Journal of Gastroenterology
A promising possibility for the treatment of the esophageal carcinoma
October 9th, 2008
Recent work demonstrates that GSK-3 beta is involved in the process of tumorigenesis, and inhibition of the expression and activity of GSK-3 beta attenuates cell proliferation and causes apoptosis in colorectal, pancreatic and ovarian cancer cells. Lithium is an existing drug for psychiatric diseases and its uptake has been linked to reduced tumor incidence compared to the general population, furthermore, lithium has been shown to be a specific and noncompetitive inhibitor of GSK-3 beta activity in vitro and in vivo. Recent researches have proved that lithium could promote or inhibit cell cycle transition and proliferation of certain primary cultures or cell lines by inhibiting GSK-3 beta...
Source: Women's Health Weekly (2008-10-09)
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