Women's Health Weekly
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Cancer
Research findings from Duke University, Medical Department update understanding of cancer
October 9th, 2008
"The type III transforming growth factor-beta receptor (T beta RIII or betaglycan) is a ubiquitously expressed transforming growth factor-beta (TGF-beta) superfamily coreceptor with essential roles in embryonic development. Recent studies have defined a role for T beta RIII in the pathogenesis of human cancers, with frequent loss of T beta RIII expression at the message and protein level," scientists in the United States report. "Mechanisms for the loss of T beta RIII expression remain to be fully defined. Advanced human cancers often have elevated circulating levels of TGF-beta 1. Here, we define a specific role for TGF-beta 1 in negatively regulating T beta RIII at...
Source: Women's Health Weekly (2008-10-09)
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