Women's Health Weekly
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Endometrial Cancer
Researchers from Technical University of Munich describe findings in endometrial cancer
October 9th, 2008
According to recent research from Munich, Germany, "Over-expression of the zinc finger transcription factor Snail leads to down-regulation of the epithelial proteins E-cadherin and Cytokeratin 18 and to upregulation of the mesenchymal protein Vimentin. The aim of our study was to characterize for the first time Snail protein expression in formalin-fixed primary tumour tissues using protein lysate microarrays and correlate Snail with E-cadherin, Cytokeratin 18, and Vimentin protein abundances." "In a first feasibility study, we examined 17 formalin-fixed endometrioid adenocarcinomas by protein lysate microarrays. Snail expression showed a statistical significant inverse...
Source: Women's Health Weekly (2008-10-09)
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