Women's Health Weekly
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Life Sciences
Researchers from University of North Carolina report recent findings in life sciences
October 9th, 2008
"D-Penicillamine (D-pen) is an established copper chelator. We have recently shown that the copper-catalyzed D-pen oxidation generates concentration-dependent hydrogen peroxide (H2O2)," scientists writing in the journal Bioconjugate Chemistry report. "Additionally, D-pen coincubated with cupric sulfate resulted in cytotoxicity in human leukemia and breast cancer cells due to the extracellular generation of reactive oxygen species (ROS). The inherent physicochemical properties of D-pen such as its short in vivo half-life, low partition coefficient, and rapid metal catalyzed oxidation limit its intracellular uptake and the potential utility as an anticancer agent...
Source: Women's Health Weekly (2008-10-09)
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