Women's Health Weekly
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Breast Cancer
New findings in breast cancer described from University of Minnesota
October 16th, 2008
According to a study from the United States, "Many anti-human immunodeficiency virus 1 nucleoside reverse-transcriptase inhibitors have low central nervous system (CNS) distribution due in part to active efflux transport at the blood-brain barrier. We have previously shown that zidovudine (AZT) and abacavir (ABC) are in vitro substrates for the efflux transport protein breast cancer resistance protein (Bcrp) 1. We evaluated the influence of Bcrp1 on plasma pharmacokinetics and brain penetration of zidovudine and abacavir in wild-type and Bcrp1-deficient (Bcrp1(-/-)) FVB mice." "There was no difference in either area under the concentration-time profiles for plasma...
Source: Women's Health Weekly (2008-10-16)
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