Women's Health Weekly
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Cancer
Data from J.M. Arif et al provide new insights into cancer
October 16th, 2008
"In the present study, we screened newly synthesized antiviral aminopyrazoloquinoline derivatives for their cytotoxic and genotoxic potential in human normal and breast cancer cell lines using apoptosis and DNA adducts biomarkers. The compounds, along with the well-known antiviral drug acyclovir, were incubated with the normal (MCF-10A, MCF-12A) and cancer (MCF-7, MDA-MB-231) cell lines at 10, 50, and 100 mc M for 72 h at 37C," scientists writing in the journal Medicinal Chemistry Research report. "The most potent antiviral methoxy derivative (compound 3) was found to be more cytotoxic in the normal breast epithelial cell lines (MCF-10A and MCF-12A) and...
Source: Women's Health Weekly (2008-10-16)
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