Massachusetts General Hospital
Extra copies of EGFR gene signal poor prognosis for vulvar cancer
Published in Women's Health Weekly, October 16th, 2008
A genetic fingerprint identified in patients with a gynecologic cancer may reveal candidates for targeted therapy. In a study in the journal Gynecologic Oncology, investigators from the Massachusetts General Hospital (MGH) Obstetrics and Gynecology Service report that women with vulvar carcinoma whose tumors have extra copies of the epidermal growth factor receptor (EGFR) gene are at increased risk of dying from their cancer. The EGFR pathway is known to be critical in several types of cancer, but this is the first association of an EGFR gene alteration with this tumor.
"Treatment for vulvar carcinoma has changed little over the years." says Bo Rueda, PhD, of the...
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