Women's Health Weekly
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Breast Cancer
Research results from T. Wiech and colleagues update understanding of breast cancer
October 23rd, 2008
"We report a case of an invasive ductal breast carcinoma with significant heterogeneity: a HER-2+ tumor component was densely infiltrated by T-cells, whereas the HER2- tumor component, including two axillary lymph node metastases, showed much fewer tumor infiltrating lymphocytes," investigators in Freiburg, Germany report. "Array comparative genomic hybridization of dissected tumor cells from both components revealed many shared chromosomal aberrations but also unique alterations of the HER2+ tumor cell population besides HER2 amplification. We found a clonally dominated T-cell receptor rearrangement of the tumor infiltrating lymphocytes in the HER2+, but not in the...
Source: Women's Health Weekly (2008-10-23)
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