Women's Health Weekly
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Cancer Gene Therapy
Researchers from University of Texas detail new studies and findings in the area of cancer gene therapy
October 23rd, 2008
According to a study from the United States, "We have reported that a gene therapy approach, using a dominant-negative estrogen receptor blocker (DN) gene, can cause cell death in cervical cancer cells in vitro. We investigated the mechanisms for enhanced cell killing when DN was combined with cisplatin (CP) and paclitaxel (TX)." "Cells were transduced with DN at 24 h and/or treated with drugs at 48 h, and harvested at 48 and 72 h after transduction. Effects were determined using the MTT cytotoxic, and TUNEL and caspase-3 activity apoptotic assays. Each agent induced cytotoxic and apoptotic effects, and activated caspase-3. In the combined treatments, significant...
Source: Women's Health Weekly (2008-10-23)
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