Women's Health Weekly
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Chlamydia
New chlamydia data have been reported by researchers at Technical University of Munich
October 23rd, 2008
"Chlamydiae replicate in a vacuole within epithelial cells and commonly induce cell damage and a deleterious inflammatory response of unknown molecular pathogenesis. The chlamydial protease-like activity factor (CPAF) translocates from the vacuole to the cytosol, where it cleaves several cellular proteins," researchers in Munich, Germany report. "CPAF is synthesized as an inactive precursor that is processed and activated during infection. Here, we show that CPAF can be activated in uninfected cells by experimentally induced oligomerization, reminiscent of the activation mode of initiator caspases. CPAF activity induces proteolysis of cellular substrates including two...
Source: Women's Health Weekly (2008-10-23)
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